Nicotinamide Adenine Dinucleotide (NAD+) is present in all cells of our body, affects DNA repair, and is also a valuable coenzyme involved in the production of energy by adenosine triphosphate molecules (ATP), which are a universal source of energy for all living organisms. NAD+ affects various biochemical processes in the body, one of which is the production of an important fat-soluble compound called ubiquinone, better known as coenzyme Q10. Of course, ubiquinone is the main participant in the synthesis of ATP molecules in the mitochondria, but no less important are the antioxidant properties of coenzyme Q10, which protect cells from damage by free radicals.  Ubiquinone is synthesised naturally in our bodies, but as we age, the natural synthesis of coenzyme Q10 gradually decreases. As a result, energy metabolism deteriorates, cognitive functions are impaired, and the ageing process accelerates. The effect of NAD+ on biochemical processes can reduce oxidative damage to cells and tissues, which has a positive effect on maintaining youthfulness.

NAD+ (Nicotinamide Adenine Dinucleotide) is essentially a component of the electron transport chain. According to scientific research, the function of this chain is to participate in electron transfer and generate energy within cells. It is believed that the NAD+ peptide acts as a neutral mediator in a number of biochemical processes in the body, including post-translational modification of proteins with the ability to activate and deactivate certain enzymes. It can certainly be assumed that the NAD+ peptide influences the maintenance of intercellular communication. 

NAD+ (Nicotinamide Adenine Dinucleotide) is a coenzyme composed of a combination of nicotinamide and adenine, whose main action is directed at the movement of energy in the mitochondria. Preclinical studies have documented processes that demonstrate pharmacological properties with potential therapeutic applications in the future. Studies have shown the importance of NAD+ in DNA repair and its influence on ageing processes. Proper functioning of this process allows the production of the necessary amount of energy, which saves cells from death.

According to researchers, NAD+ is an important component of the electron transport chain, participating in electron transfer, which enables energy-producing processes within cells. The properties of NAD+ allow this peptide to create favourable conditions for various physiological processes in the form of activation and deactivation of certain enzymes, as well as in post-translational modification of proteins, and can be characterised as a mediator of these processes. The NAD+ peptide is one of the most important sources of energy generation in maintaining intercellular communication. 

Recent studies of NAD+ demonstrate the possibility of therapeutic use for various purposes in pharmacological production. One of the most thoroughly studied areas is the effect of NAD+ on the functioning and vital activity of the body.

NAD+ ANTI-AGING THERAPY:

 Thanks to its properties, the NAD+ peptide potentially possesses all the qualities of an elixir of youth – after all, it is precisely the decrease in its level with age that is accompanied by oxidative stress, which affects the condition of the skin and accelerates the development of chronic and metabolic diseases. It is the effect of NAD+ on metabolism that helps regulate blood sugar, which is extremely important for people suffering from diabetes or obesity. The effect of NAD+ on improving mitochondrial function creates conditions for more efficient calorie burning, which is critical for maintaining a healthy weight for proper body function.

The NAD+ peptide is an important component in protecting against cell death. Mitochondria are fundamental to the metabolic process associated with intracellular signalling and the regulation of the body's own immune system. Based on research findings regarding NAD+, a deficiency of which alters cellular metabolism, manifested by mitochondrial ageing, suppression of stem cell activity, and increased inflammatory processes. All these manifestations demonstrate the importance of mitochondria in the deterioration of body function caused by age-related changes in ageing tissue and organ cells. The hypothetical potential of influencing mitochondrial activity certainly opens up the possibility of slowing down the processes caused by cell ageing and, to some extent, halting age-related changes with the possibility of reversing them. 

With an excess of NAD+ in the cell, we receive continuous signalling in the nucleus, which allows us to avoid a pseudo-hypoxic state. By preventing NAD+ deficiency in an ageing organism, we ensure that the body activates the coding function of the SIRT1 enzyme at the genetic level. Mediators involved in metabolism, inflammation, and cell lifespan are regulated by sirtuin proteins, which act as cofactors for various enzymatic reactions, from gene expression to DNA repair.

In addition to its potential benefits in anti-ageing therapy, the NAD+ peptide has other useful characteristics:

Reverses neuron degeneration

Has a protective effect on the heart and nervous system

Reduces the likelihood of developing diseases such as Alzheimer's and Parkinson's

Slows down the rate of skin cell degeneration

Promotes regeneration and increases vitality

Improves insulin sensitivity

Prevents age-related weight gain

Improves plasma lipid levels

Promotes ATP energy production in mitochondria

Has certain value as an elixir of youth

Is important for the production of the powerful antioxidant glutathione

There are various injectable forms of NAD+, and many people wonder how they differ and which NAD+ is better. NAD+ is most often found in the form of a lyophilised powder or in a dissolved form filled into an insulin injection pen, often called a peptide pen (Pen peptide).

HOW TO TAKE NAD+:

Since NAD+ is used only for research purposes, the results of such studies have yielded  working values that allow you to configure the duration of intake and the required dosage. In these studies, NAD+ is most often  taken 3 times a day, with one day of rest. This alternation is considered to be the correct and relatively safe way to consume NAD+. The studies concluded that the recommended daily dosage of NAD+ equivalent to 100 mg can be considered relatively safe.

Let's look at this NAD+ course schematically using an example.

For example, the active ingredient NAD+ is 300 mg.

We divide the content into 3 days for intake of 100 mg each day.

We divide the daily dose of NAD+ into three parts for intake: one part in the morning, the second part at lunchtime, and the third part in the evening. The minimum time interval between NAD+ intakes should be at least 3 hours.

The next day is a rest day.

Day 1 — conditionally recommended dosage of 100 mg divided into three parts to be taken in the morning, at noon, and in the evening.

Day 2 — rest day without taking NAD+.

Day 3 — conditionally recommended dosage of NAD+ 100 mg divided into three parts to be taken in the morning, at noon, and in the evening.

Day 4 — rest day without NAD+ intake.

Day 5 — conditionally recommended dosage of 100 mg divided into three parts to be taken in the morning, at noon, and in the evening.

Day 6 — rest day without NAD+ intake.

Possible side effects of taking NAD+ recorded during studies. Although NAD+ is just a molecule that is present in the body in its natural environment, uncontrolled intake of NAD+ can be accompanied not only by headaches, but also by severe diarrhoea combined with nausea and itchy skin. 

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